【摘要】 应用间接荧光抗体试验对江苏省两个采取不同抗疟措施地区的人群在1982年间进行了连续4次的纵向观察。单纯采取现症病人治疗措施的对照组178例,治疗病人加上室内滞留喷洒与孳生地灭蚊的灭蚊组182例。在措施期间的3、6、8及10月各调查1次。结果,两组的抗体阳性率与几何平均倒数滴度均随年龄增长而升高,3月份两组抗体阳性率差异不显著,在其他三次调查中,灭蚊组均低于对照组,4～15岁年龄组尤明显。提示药物治疗加灭蚊对控制疟疾的效果较好。间接荧光抗体试验的结果与疟原虫调查及随访结果相符,而低年龄组的血清学资料较易反映这一变化。同时证明间接荧光抗体试验可用于评价抗疟措施的效果。更多还原

【Abstract】 A longitudinal seroepidemiological survey of malaria was performed using the indirect fluorescent antibody test(IFAT), in a malarious area of Jiangsu Province where different anti-malaria measures were adopted in March, June, August and October o?1982.Of all 360 villagers examined, 178 were from Guomiao Brigade where antimalarial drug ware administrated to patients with Plasmodium vivax and febrile cases and 182 were from Baoshan Brigade where residual spraying of houses and management of breeding places around the villages with insecticides together with chemotherapy were carried out.The results showed no significant difference in the positive percentages between the two groups in March,but a significantly lower percentage of positives in Guomiao Brigade in the other three months than that in Baoshan Brigade. The GMRT in 4-15 year age population in the former village was much lower than that in the latter. This suggests that a combination of drug therapy and vector control was more effective in the control of malaria transmission.The changes in antibody titers detected by IFAT in all the populations were coincident with malaria incidence and parasitological investigations.This study shows that IFA test can be used to assess the effect of anti-malaria measures in the control of malaria.更多还原