【摘要】 <正> 棉酚是我国首创的男性避孕药物,其作用机理、生殖生理、毒理学、体内代谢及遗传学效应等方面已有大量研究资料。1977年以来,在妇科临床开始应用醋酸棉酚治疗妇女功能性子宫出血、子宫肌瘤合并出血过多和子宫更多还原

【Abstract】 Since 1977 gossypol acetic acid has been using in China for certain gynecological conditions. It was found to be effective in the treatment of myomata of the uterus and endome triosis.In order to determine the safety of this drug, We compared the frequ encies of SCE in peripheral lymphocy tes of 30 patients who had taken the drug and 30 normal women. The frequencies of SCE were 7.82卤2.41 (SD) /cell and 6.94卤1.49 (SD)/cell respectively. The differences were not statistically significant (P>0.05).The rasults of the self control group of 20 patients showed that there were no statistically significant differences between the three sub-groups, i. e. pre-treatment (7.35 卤2.31 (SD) /cell) , during treatment (4-6 months) (8.13卤 2.31 (SD) /cell) and 2 months after discontinuance of medication(8.56 卤 5.13 (SD)/cell).In conclusion,gossypol acetic acid exerts no significant effect on SCE of peripheral lymphocytes.更多还原