【摘要】 本文对生产环氧氯丙烷工人及27例氯丙烯中毒性神经炎患者的十三年动态观察进行总结。并探讨了氯丙烯中毒诊断标准和早期诊断指标。动态观察结果大部分病例在六年后体征基本消失,肌电不再出现失神经电位,少数重症患者至今仍留有症状、体征和肌电改变。诊断主要依据氯丙烯接触史、神经炎的主要症状、体征和相应的肌电改变。资料表明四肢酸、麻、抽筋、无力、感觉障碍和腓肠肌压痛是中毒早期临床表现,而肌电改变出现更早,对早期诊断具有特殊意义。更多还原

【Abstract】 This paper summarizes a ten-year observation on epichlorohydrin manufacturing workers and a follow up study of 27 cases of toxic neuropathy due to long term exposure to allyl chloride. Diagnostic criteria and early diagnostic indexes of allyl chloride poisoning are also discussed. The result of the observation showed that signs of toxic neuropathy in most cases disappeared in six years, and the denervated potential of electromyography was no longer present. But the signs and symptoms of neuropathy as well as its corresponding changes in electromyography suggesting the diagnosis lingered in a few serious cases. The data available showed that early manifestation of allyl chloride poisoning might include soreness, numbness, cramp, weakness and sensory dysfunction of the extremities, and tender pain of gastroenemius muscle, with eleetromyographic changes occurring early in illness. Consequently, the EMG changes have proved to be particularly significant for early diagnosis of the disease.更多还原