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辽宁省血红蛋白病调查报告

MASS SURVEY OF PATIENTS WITH HEMOGLOBINPATHIES AMONG THE POPULATION IN LIAO-NING PROVINCE

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【作者】 付权舟王静珍刘永琴刘作芳许国瑄申玉璋

【Author】 Fu Quanzhou, et al (Department of Internal medicine, First Affiliated Hospital)

【机构】 中国医科大学附属第一医院内科中国医科大学附属第一医院内科

【摘要】 本文报告了辽宁省血红蛋白病的调查情况,普查人群12,686人,包括汉、满、蒙、回、朝鲜及锡泊族六个民族。对辽宁省血红蛋白病的人群发生率,类型及地理分布进行了探讨。

【Abstract】 Abnormal hemoglobins were investigated in 12, 165 normal subjects of the populatien of 10 cities and 2 districts in Liao-Ning Province. The result of investigation showed that 16 cases with abnormal hemoglobins distributed in 8 cities and 2 districts. An over-all incidence of the disorder was 0.13%. The blood samples drawn from 16 cases were analysed with electrophoresis on cellulose acetate membrane at pH 8.5. Abnormal hemoglobins, in 12 cases of whom, were separated and located in D fraction of the slow speed zone and in J fraction of the fast speed zone in 2 cases. In the remainder, an increase in Hb A2 was recognized on electrophoresis. All of 16 cases exibited familial histories of the disorder. A pedigree of 10 probands with 65 members in their families was investigated. Among them, abnormal hemoglobins were found in 33 cases. This provided an evidence that hereditary factor may play an important role in the pathogenesis of the disorder.

  • 【文献出处】 中国医科大学学报 ,Journal of China Medical University , 编辑部邮箱 ,1985年03期
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