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变色马兜铃石油醚可溶性成分的分离和鉴定

ISOLATION AND IDENTIFICATION OF THE CONSTITUENTS SOLUBLE IN PETROLEUM ETHER FROM ARISTOLOCHIA VERSICOLAR

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【作者】 薛慧中张玖何林兴

【Author】 Xue Hui-zhong;Zhang Jiu;He Lin-xing Nanjing Institute of Materia Medica

【机构】 南京药物研究所南京药物研究所

【摘要】 从变色马兜铃Aristolochia versicolar S.M.Hwang块根醇提物的石油醚溶解部分中分得12个结晶性成分,其中8个化合物经化学和光谱测定分别鉴定为豆甾-4-烯-3,6-二酮、豆甾烷-3,6-二酮、β-谷甾醇、马铃兜酸A、马兜铃酸A-甲酯、6-甲氧基马兜铃次酸甲酯、胡罗卜甙和硬酯酸。其余三个可能为新化合物。经药理试验,马兜铃酸A和6-甲氧基马兜铃次酸甲酯(B5)具抗生育作用,豆甾-4-烯-3,6-二酮具细胞毒活性。

【Abstract】 Twelve crystalline constituents were isolated from petroleum ether fraction of the root of Aristolochia versicolar S. M. Hwang(B). By chemical and spectrosco- dic analysis, eight compounds were identified as stigmast-4-en-3,6-dione,stigmas- tane-3, 6-dione, β-sitosterol, aristolochic acid A, aristolochic acid methyl ester, 6-methoxy-aristolic acid methyl ester, β-sitosterol-D-glucoside and stearic acid. The other three were proposed to be new compounds. Aristolochic acid A and 6- methoxy-aristolic acid methyl ester showed antifertility activity and stigmast-4- en-3, 6-dione exhibited cytotoxicity.

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