【摘要】 本文以7-ACA为原料制备了7-ACT,再以DCC为缩合剂与侧链2(2-氯乙酰氨基噻唑-4)-(Z)-2甲氧亚胺乙酸进行缩合,使用N-甲基二硫代氨基甲酸甲胺盐脱保护基,以葡聚糖凝胶LH-20精制合成了氨噻肟唑头孢菌素;总收率35.8％。产物经~1H核磁确证为顺式构型化合物。更多还原

【Abstract】 Cefmenoxime was synthesized by a four-step method with overall yield of 35.80%. The conversion of 7-ACA to 7-ACT with 1-methyl-1H-tetrazole-5-thiol, the condensation of the side-chain 2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-me- thoxyimino-acetic acid with DCC as condensing agent, the removal of the pro- tecting group with N-methyl-dithiocarbamate methyl amine salt and the purifi- cation of the crude product on sephadex IH-20 column were processed.更多还原