【摘要】 N-甲基异靛兰（代号靛Ⅲ）,为靛玉红的类似物,对小鼠Lewis肺癌及大鼠Walker256有明显抑瘤作用,但对小鼠白血病L₁₂₁₀。无效。对小鼠Lewis肺癌的疗效靛Ⅲ至少相当靛玉红的8倍。对狗的毒性靛Ⅲ比靛玉红高1倍多,主要毒性表现为胃肠道反应。该药无论腹腔注射或口服均可抑制[³H]-TdR掺人大鼠Walker 256瘤细胞DNA。更多还原

【Abstract】 N-methylisoindigotin （Dian Ⅲ） is an analogue of indirubin. When given orally it exhibited significant inhibition against Lewis lung cancinoma and Walker carcinosarcoma 256. However, the effect of Dian Ⅲ on the growth of L₁₂₁₀ lymphocytic leukemia was insignificant. Dian Ⅲ was shown to be 2 times more toxic than indirubin in dogs and exhibited an inhibitory action against Lewis lung carcinoma 8 times as great. Dian Ⅲ given orally or intraperitoneally markedly inhibited the incorporation of [³H]-TdR into DNA of Walker 256 tumor cells in rats.更多还原