【摘要】 本文以二甲苯诱发的小鼠耳部炎症模型研究了Lut抗炎作用的量效与时效关系。 Lut肌内注射对二甲苯诱发的小鼠耳部炎症有明显的抑制作用,其抗炎作用与剂量间呈线性关系,ED₅₀为106mg/kg。致炎前肌内注射Lut 158mg/kg,0.5小时起效,致炎前0.5～2.5小时用药,抗炎作用达高峰,致炎前6.5小时用药仍有效,唯作用强度明显降低。提示Lut的抗炎作用发生较快,且维持较久。更多还原

【Abstract】 It was found that the drug exhibited significant anti-inflammatory effect on oedema induced by dimethyl benzene in mouse ear when injected im 81-159mg/kg.The results showed a linear relationship between the decrease of oedema and the log-dose of luteolin. The duration of its initial effect on dimethyl benzene-induced oedema was studied when administered before application of dimethyl benzene to mouse ear. From 0.5 to 2.5 hours before the dimethyl benzene was given,their activity showed a maximal effect.When given 6.5 hours before using dimethyl benzene,they were still effective,but the effect was significantly decreased.更多还原