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含5%石英的白刚玉粉尘对大鼠肺脏致纤维化作用

EFFECTS OF CORUNDUM CONTAINING 5% QUARTZ ON THE FIBROSIS OF THE RAT LUNG

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【摘要】 <正> 生产现场常见为两种或两种以上的混合性粉尘。混合性粉尘的致病性不外乎有增强或减弱致纤维化作用。铝及氧化铝是一种颇有趣味的粉尘,有人用铝和铝制剂进行矽肺防治取得效果。同时,也有越来越多的材料证实铝和氧

【Abstract】 A study of some dusts on fibrogenic effect was made, corundum, corundumquartz mixtures (containing 5% quartz), quartz and saline control Were administrated intratraeheally. Each rat of the group received dose of 50 mg dust respectively. All rats were killed at intervals of 1, 3, 6, 12 and 18 months after administration.It was found that rats of quartz group produced more fibrosis and also produced marked increase of the wet weight and dry weight and the collagen content of lung. Rats of corundum group were mild fibrosis The fibrosis of rat lung due to mixtures was milder than that in corundum group.

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