【摘要】 <正> 我们在1975年首先报道,给家兔脑室注射5-羟色胺(5-HT)合成阻断剂对氯苯丙氨酸(PCPA)使间脑和低位脑干5-HT含量分别降低79.2％和48.5％,电针镇痛效果减弱63％。1976年又报道给大鼠腹腔注射pCPA300mg/kg使脑干、间脑、端脑5-HT含量分别降低73.2％、77.2％和85.1％,电针镇痛效果降低79％,上述效应并可为腔室注射5-羟色胺酸所翻转,从而认为中枢5-羟色胺在电针镇痛中起着重要作用。这一结论得到其后很多工作的支持。更多还原

【Abstract】 Evidences obtained from different lines have shown that 5-hydroxytry- ptamine (5-HT) plays an important role in mediating electroacpuncture ana- lgesia (EAA). However, Cheng and Pomeranz in 1979 reported that p-chlo- rophenylalanine(pCPA), the specific inhibitor of the 5-HT synthetic enzy me, was effective in decreasing only high frequency EAA, but not the low frequency EAA in the mice. To evaluate whether this is true in the rat, we have used EA of 4 frequencies (2, 15, 100Hz fixed frequency and 2-15 Hz changing frequenecy EA stimulations) and 2 intensities (3V, 9V) to assess the effect of pCPA on EAA. The effect of EAA in control rats injected with normal saline were rather stable in a period of 2 weeks. Intraperitoneal injection of pCPA 320mg/kg) resulted in a marked decrease (-84% to-90%) of the effect of EAA 3 and 5 days after the ip injection, followed by a gradual recovery which completed in 13 days. The decrease of EAA was of similar degree whether low or high frequency, weak or strong intensity EA stimulations were used. It is thus concluded that 5-HT is important in mediating not only high frequency, but also low frequency EA analgesia in the rat.更多还原