【摘要】 <正> 自身免疫性多腺体综合征(AutoimmunePolyglandular Syndrome 简称 APG 综合征)系指同一病人先后或同时存在2种或2种以上自身免疫性疾患,且其中至少有一更多还原

【Abstract】 The autoimmune polyglandular syndrome is characterized by the coexistence oftwo or more autoimmune disorders with clinical involvement of at least one endocrinetissue.This article reports 11 cases of APG syndrome.All of them have had evidenceof two or more autoimmune endocrine diseases such as autoimmune thyroid disease,Addison’s disease,primary hypoparathyroidism or insulin-dependent diabetes mellitus.In the 11 cases,2 cases are type Ⅱ APG syndrome and 9 cases are type Ⅲ APG syn-drome.The ratio of male to female is 2:9.Continued suspicion of more than one glandular disease should be maintained inpatients with any type of autoimmune endocrine diseases,since the risk of multipleglandular involvement is significant.Family members should be alerted to the highprevalence of endocrinopathies especially among the first-degree relatives of patientswith APG syndrome.Parameters such as antiorgan autoantibodies have not beenshown to be consistently useful in predicting the future development of clinical organ-specific autoimmune disease.It must be recognized that autoimmunity is not the onlycause of multiple glandular insufficiencies.Hypopituitarism and a number of infiltra-tive disorders may present as polyglandular insufficiency.In addition it is necessaryto consider the interrelationship among involved glands during treatment.更多还原