【摘要】 <正> 冠心病是危害人类健康和长寿的常见病之一。为了掌握有利时机,及早采取预防和有效治疗措施,对其早期形态学变化及其动态衍化规律的研究就显得特别重要。本文旨在应用实验方法研究家兔缺血心肌的早期病变,其中包括光镜、组织化学和超微结构的变化。并就β肾上腺素能阻滞剂——心得安对缺血心肌的影响做了初步探讨。更多还原

【Abstract】 Experimental study of myocardial ischemia is one of the important methodsfor the investigation of early morphologic changes of myocardium.After ligation ofleft descending coronary artery for half an hour myonecrosis oecured.After twohours occlusion of the left descending coronary artery the extension of the myone-crosis was about two fold of that of half an hour.Thus the longer the duration ofmyocardial ischemia,the more the myoneerosis occured.The main ultrastructural fin-dings of the ischemic myocardium were focal myofibriolysis and fragmentation ofmyofibril.To another group of animal propranol was injected intravenously 10 minu-tes before ligation of the left descending coronary artery.The extent of myonecrosisand myodegeneration was less than that of the former group.Above results sug-gested that β-adrenergic blocking drugs may protect theisehemic myocardium frominjury to some extent.更多还原