【摘要】 <正> 预防围产儿呼吸窘迫综合征(RDS)是围产医学的一项重要措施,1971年 Gluck等提出以羊水卵磷脂/鞘磷脂(L/S)比值预测胎肺成熟度,L/S>2谓肺成熟。RDS的发生和肺表面磷脂类的减少有关,与磷脂酰甘油(PG)缺少关系尤为密切。本室于1983年11月～1984年11月建立了 PG 的测定方法,为更精确地监测围产儿的肺成熟度增添了手段。更多还原

【Abstract】 RDS was related to the reduction of lung surfactant,especially the absence ofPG.Our laboratory analyzed both the test for PG and L/S ratio in 90 amniotic fluidsamples with two-dimensional thin-layer chromatography.Specimens contaminated withmeconium and blood or vaginal secretions did not interfere the results of PG analysis.In 50 cases of gestational age≥38 weeks,90% (45/50) of them had L/S ratio≥2and 96% (48/50) of them were PG positive.Three of the 50 cases suffered from severe preeclampsia had L/S ratio<2 but PGwas positive,and the newborn infants did not present RDS.Thus,we suggested thattest for PG is more sensitive than L/S ratio for the prediction of the fetal lungmaturity.It is even more accurate by using two or more indexes to assess the fetallung maturity and to monitor the high risk pregnancies for the prevention of RDSand the reduction of perinatal infant mortality.更多还原