【摘要】 <正> 地方性甲状腺肿的病理形态学变化及其演变过程在我国已有不少报导,在甲状腺肿发病的早期主要表现为弥漫性甲状腺肿,以后逐渐发展为结节性甲状腺肿。近年来又报导了地方性甲状腺肿流行区人工流产胎儿甲状腺肿的形态特点。为了探讨地方性甲状腺肿的早期形态学演变规律,本文研究了流更多还原

【Abstract】 14 cases of therapeutically aborted fetuses with intrauterine ages of 4.6 and 8months collected from the regions of endemic goiter were analyzed.The thyroid tis-sues were examined histopathologically and by immunofluorescent methods for Tg &T4.7 cases were examined with electron microscope.The results were as follows:(1)Thyroid tissue showed marked hyperplasia and hypertrophy of the epithelial cellswith premature formation of thyroid follicles as compared with that of the non-endemic region.(2)The ultrastructural features showed dilated cisternae of RERand dilatation of the intercellular spaces which were filled with homogeneous material.(3)The observations of strongly positive reaction of Tg and the weakly positivereaction of T4 in the goitrous tissues seem to suggest that the development of ende-mic goiter in the intrauterine period may be chiefly by hyperplasia and hypertrophyof the follicular epithelial cells.The dilatation of RER cisternae and the intercellu-lar spaces together with the strongly positive reaction for Tg may be rèlated to thecompensatory reaction of the thyroglobulin synthesis.The weak immunofluorescentreaction for T4 is correlated with the lowering of T4 level in the cord blood of thegoitrous fetuses which was proposed to be the result of iodine deficiency in the ende-mic region.更多还原