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猫肺血管顺应性与反应性研究

Studies on Pulmonary Vascular Compliance and Responsiveness in Cats

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【作者】 邹爱平; 陈琪玲; 吴锋;

【Author】 Zou Aiping,Chen Qiling,Wu FengDepartment of Pathophysiology,Faculty of Basic Sciences,Tongji Medical Universty,Wuhan

【机构】 同济医科大学基础医学部病理生理学教研室; 同济医科大学基础医学部病理生理学教研室;

【摘要】 本文研究了猫肺血管在不同功能状态下的顺应性与反应性。结果显示,静注去甲肾上腺素(NA)、组织胺(HiS)及肺泡缺氧均使肺血管顺应性指数(CIPA)降低;异丙肾上腺素(Iso)则使之升高。在缺氧及注NA时,用肺阻抗血流图与肺动脉平均压变化两种方法,测得的肺血管反应性明显相关;肺血管反应与肺血管顺应性变化也明显相关。

【Abstract】 Pulmonary vascular compliance and responsiveness in feline under various functional conditions have been studied.The results showed that compliance index of pulmonary arteries (CIPA) decreased during infusion of noradrenaline (NA) and histamine as well as during alveolar hypoxia:it was,however,increased during infusion of isoprenaline.Impedence-pulmonary rheogram and changing in mean pulmonary arterial pressure were used to determine the responsiveness of pulmonary blood vessels to hypoxia and vasoactive drugs.A linear correlation was demonstrated between the decrease in the amplitude of pulmonary rheogram and the increase in mean pulonary arterial pressure during hypoxia and infusion of NA.There was also a negative linear correlation between the responsiveness of pulmonary blood vessels and the variation of CIPA during hypoxia and infusion,of NA.

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