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合成前列腺素E1的中间体-γ亚麻酸甲酯的制备
PREPARATION OF THE INTERMEDIATE MATERIAL FOR SYNTHESIZING PROSTGLANDIN E1 FROM PLANT RESOURCES—METHYL γ-LINOLENATE
【摘要】 以r-亚麻酸甲酯为原料可合成二高-r-亚麻酸,再经生物合成得前列腺素E1。本文报道了由月见草(Oenothera biennis)种子油制备 r-亚麻酸甲酯的方法。所得产品为无色或微带黄色的油状液体,含有 r-亚麻酸60%(GLC)以上。按月见草油计算,总收率约3%。
【Abstract】 Dihomo-γ-Linolenic acid was obtained chemically using methyl γ-linolenate as starting material.It could then be converted into prostglandin E1 through bio- synthesis.In this paper,a modern method for preparing methyl γ-linolenate from the seed oil of Oenothera biennis was reported.The product obtained was a col- ourless or light yellowish oil.The content of γ-linolenic acid was higher than 60%(GLC).The total yield was about 3% caculated on the weight of the seed oil.
【关键词】 月见草;
r-亚麻酸;
r-亚麻酸甲酯;
二高-r 亚麻酸;
前列腺素 E1;
【Key words】 Oenothera biennis; γ-Linolenic acid; Methyl γ-1inolenate; Dihomo-γ-linolenic acid; Prostaglandin E;
【Key words】 Oenothera biennis; γ-Linolenic acid; Methyl γ-1inolenate; Dihomo-γ-linolenic acid; Prostaglandin E;
- 【文献出处】 沈阳药学院学报 , 编辑部邮箱 ,1985年02期
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