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合成前列腺素E1的中间体-γ亚麻酸甲酯的制备

PREPARATION OF THE INTERMEDIATE MATERIAL FOR SYNTHESIZING PROSTGLANDIN E1 FROM PLANT RESOURCES—METHYL γ-LINOLENATE

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【作者】 高雅琴李霞冰朱廷儒

【Author】 Gao Yaqin Li Xiabing Zhu Tingru Institute of Forestry and Pedology,Academia Sinica,Shenyang

【机构】 中国科学院林业土壤研究所中国科学院林业土壤研究所

【摘要】 以r-亚麻酸甲酯为原料可合成二高-r-亚麻酸,再经生物合成得前列腺素E1。本文报道了由月见草(Oenothera biennis)种子油制备 r-亚麻酸甲酯的方法。所得产品为无色或微带黄色的油状液体,含有 r-亚麻酸60%(GLC)以上。按月见草油计算,总收率约3%。

【Abstract】 Dihomo-γ-Linolenic acid was obtained chemically using methyl γ-linolenate as starting material.It could then be converted into prostglandin E1 through bio- synthesis.In this paper,a modern method for preparing methyl γ-linolenate from the seed oil of Oenothera biennis was reported.The product obtained was a col- ourless or light yellowish oil.The content of γ-linolenic acid was higher than 60%(GLC).The total yield was about 3% caculated on the weight of the seed oil.

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