【摘要】 川芎嗪是从中药川芎根中提取的一种生物碱。祖国医学对其活血化瘀作用早有所知。其化学结构已查明,并有合成制品在市上销售。 临床试用表明,川芎嗪治疗冠心病、心绞痛和急性闭塞性脑血管病有效。本文研究证明,川芎嗪在体外对由诱导剂二磷酸腺苷、胶原、凝血酶诱导所致的家兔血小板聚集有强烈抑制作用,同时也能抑制血小板丙二醛的生成。对外源性花生四烯酸诱导的血小板聚集则无抑制作用。川芎嗪能加强家兔动脉环保温液对花生四烯酸诱导的血小板聚集的抑制作用。 给家兔静脉注射大剂量花生四烯酸钠盐,可使动物突然死亡。但如预先注射川芎嗪,则可使动物得到一定保护。更多还原

【Abstract】 Ligustrazine is an alkaloid extracted from the root of Ligustium wallichii Frachet which has long been known to be effective in"improving the circulation of blood and relieving clot formation"(HUOXUE HUAYU) in Chihese traditional medicine. The chemical structure of Ligustrazine has been determined and synthetic product has been put on the market.The clinical trials revealed that Ligustrazine was effective in the treatment of patients with angina pectoris in coronary heart diseases and acute occlusive cerebro-vascular diseases as well.our in vitro study proved that Ligustrazine could strongly inhibit platelet aggregation induced by ADP, collagen, thrombin, and reduce the production of MDA from platelets; but showed no inhibitory effect on the exogeneous arachidonic acid-induced platelet aggregation. However, while injected intravenously into rabbits prior to the administration of large doses of sodium arachidonate, which would invariably lead to sudden death, Ligustvazine could potentiate the inhibitory action on arachidonic acid-induced platelet aggregation similar to that of the solution of incubated rabbit arterial rings and protected the rabbits from death.更多还原