【摘要】 对10只麻醉下主胰管内插置导管的家狗进行急性实验。用放射免疫测定法测定静脉注射促胰液素（8μg/kg）和八肽胆囊收缩素（CCK₈,40ng/kg）以及电刺激胸迷走神经前后的胰液和血清中胰多肽的含量。结果表明,基础胰液中含有大量胰多肽免疫活性物质,平均排出量为3130±2200pg/15min,其平均浓度高于血清水平40倍左右,但是个体之间的变异范围较大。当静脉注射促胰液素和 CCK₈以及电刺激胸迷走神经后,胰液胰多肽排出量和血清胰多肽水平均增多,其中以电刺激迷走神经后尤为明显。高峰都在刺激后15min 内出现。经促胰液素,CCK₈和迷走神经刺激后,胰液中胰多肽排出量比刺激前分别增加105%,52%和200%。外源性促胰液素或 CCK₈刺激后,胰液中胰多肽与 HCO₃^-出量之间或胰液中胰多肽与淀粉酶排出量之间,分别均呈一致的关系。本文结果提示,胰多肽不仅是一种内分泌,它亦具有外分泌的特性。迷走神经、促胰液素和胆囊收缩素对胰多肽的释放具有调节作用。更多还原

【Abstract】 In acute experiments on anaesthetized dogs,pancreatic polypeptide（PP）con-centrations in pancreatic juice collected from a cannula and in serum were measuredby radioimmunoassay after intravenous injection of secretin（8μg/kg）or cholecy-stokinin octapeptide（CCK₈,40 ng/kg）.Similar measurement was made before andafter electrical stimulation of thoracic vagus.It was found that a significant amount of PP-like immunoreactivity waspresent in the basal pancreatic juice with a mean output of 3130±2200 pg/15min which was approximately 40-fold higher than that in serum.There was,however,a marked individual variations.After injection of secretin or CCK₈or after electrical vagal stimulation,the levels of PP in serum and PP output of pan-creatic juice were significantly increased（P<0.01）,particularly after electricalvagal stimulation.The peak levels of PP output in response to the three waysof stimulation mentioned above usually appeared at the first 15-min period.Themean increased values of PP released into the pancreatic juice by secretin,CCK₈,and vagal stimulation were respectively 105%,52%,and 200%.Exogenoussecretin induced increase of PP goes parallel with that of bicarbonate output in thepancreatic juice,and so is the increase of PP and amylase output in response to CCK₈stimulation.We conclude that pancreatic polypeptide is not only an endocrinebut also an exocrine,the release of which may involve the action of secretin andcholecystokinin and vagal activity.更多还原