【摘要】 于14条清醒狗静脉内匀速注射硝普钠造成急性实验性低血压时(动脉收缩压从131±6mmHg 降至94±4mmHg),在中脑中央灰质、下丘脑腹内侧核区、中脑中缝核旁网状结构微量注射东莨菪碱20μg(溶于2μl生理盐水),可以阻断电针的升压作用。如果在低血压清醒狗中于上述中枢部位微量注射乙酰胆碱(ACh)200μg(溶于2μl生理盐水),可引起血压明显回升(收缩压从94±4mmHg 升到110±6mmHg,P<0.01),持续约10min。实验结果表明:用舒血管药物造成实验性低血压时,电针引起的升压作用与中脑中央灰质、下丘脑腹内侧核区、中脑中缝核旁网状结构等部位的胆碱能 M 受体的激活有关。更多还原

【Abstract】 In 14 conscious dogs implanted with stainless steel cannulae,the effect of mi-croinjection of the cholinergic agonist or antagonist into various brain areas on thepressor effect of electroacupuncture(EA)was investigated.Following microin-jection of scopolamine(20 μg dissolved in 2 μl isotonic saline)into the midbraincentral gray(CG),the midbrain reticular formation(RF)and the ventromedialhypothalamus(VMH)in hypotensive dogs induced by infusion of sodium nitro-prusside(NP),the pressor effect of EA was blocked.On the other hand,acetylcholine(ACh,200 μg dissolved in 2 μl isotonic saline)microinjected into those areaselicited a pressor effect(P<0.01),which lasted about 10 min.It is suggested thatthe pressor effect of EA during NP hypotension was mediated by the activation ofthe muscarinic receptors in CG,RF and VMH.更多还原