【摘要】 提要家兔149只,用钾离子透入法测痛,电针单侧“合谷”和“外关”穴,观察阿片受体σ型激动剂氯胺酮以及阿片受体μ型激动剂芬太尼和多巴胺(DA)受体拮抗剂氟哌啶联用对针刺镇痛的影响。实验结果提示,阿片受体μ型激动剂芬太尼和DA受体拮抗剂氟哌啶联合应用,对针刺镇痛有增效作用,而σ型激动剂氯胺酮则有拮抗针刺镇痛的效应。更多还原

【Abstract】 The potassium iontophoretie dolorimetry was used to determine the pain threshold in 149 rabbits. Unilateral "hegu" and "Waiguan" points of each rabbit were electrically needled. Ketamine, putative σ agonist and a combination of droperidol, dopaminergio receptor antagonist and fentanyl, μ agonist were injected intravenously to determine their effects on acupuncture analgesia. The experimental results indicate that there is a potentiating effect of the combination of droperidol and fentanyl on acupuncture analgesia, but ketamine, a putative σ agonist elicits an antagonistic effect to acupuncture analgesia.更多还原