【摘要】 敌枯双农药属中等毒性,雌性大鼠和小鼠分别经口及腹腔注射的LD₅₀为253和501.5mg/kg。该药对大鼠和小鼠的致畸作用呈剂量效应关系,在高剂量的阳性对照组,即于妊娠第10d给小鼠和大鼠的剂量分别为50和2.5mg/kg,对母鼠的体重出现抑制,有大量的胚胎吸收,其吸收率分别为39.8和46.7％,仔鼠的畸胎发生率分别为56.3和6.8％。1ppm仅见母鼠的体重增长及仔鼠生长发育受抑制,未见仔鼠畸形。0.1ppm组和喷洒三次敌枯双农药的稻谷组的大鼠和小鼠的母鼠和仔鼠均无不良影响。更多还原

【Abstract】 MATDA is a pesticide with moderate toxioity, LD50 is 253 mg/kg for female rats with drug administered by gavage and 501.2 mg/kg for female mice with drug given intraperitoneally. It has teratogenic effects in rats and mice, with on evident dose-response relationship. In the positive control group of high dose MATDA, a single dose of 50 and 2.5mg/kg MATDA was given respectively to mice and rats on the 10th dey of gestation. The results showed that maternal weight gain was significantly retarded, the incidences of resorption of embryos were 39.8 and 46.7% and malformed fetuses, 56.3 and 6.8% respectively. In the experimental rat groups, when given 1 ppm, there appeared only slight depression of maternal body weight gain and embryofetal development, no malformed fetus was found. At 0.1 ppm neither the dams nor the fetuses were affected. In the group fed by the rice grain with less than 0.04ppm residue MATDA, after spraying three times, no harmful effects occurred to the rats or mice, either dams or fetuses.更多还原