【摘要】 本文证明包甲素苯甲酸盐(Benzoate of Boa-Jia-Su-A;BB-A)的中枢M-胆碱样作用与传统的中枢M-胆碱激动剂Oxotremorine(Oxot)及Tremorine(Trem)作用相似,BB-A的作用强度介于两者之间,BB-A与Trem合用产生协同作用,而东莨菪碱合用则拮抗之,通过Q值①与拮抗系数分别测定药物之间的协同拮抗强度。治疗巴金森氏症常用药安坦可选择性拮抗BB-A的中枢作用,实验未观察到美多巴能拮抗BB-A与Oxot的中枢作用,提示BB-A是一个有希望的制造巴金森氏症病理模型的工具药。更多还原

【Abstract】 The central M-Ach effect (tremor, rigidity etc.) of Benzoate of Baogongteng-A(BB-A) is the same as that of oxotremorine and tremorine. The ED 50 of BB-A is approximately 500 times of oxotremorine’s and one fifth of tremorine’s. BB-A combined with tremorine produces synergism and reduces ED 50 from 2.15mg/kg to 0.65mg/kg. Tremor and rigidity induced by BB-A or oxotremorine are antagonized by scopolamine. Artan, a commonly used drug to treat Parkinsonism, can selectively antagonize the central M-Ach effect induced by BB-A and oxotremorine, but more effective on tremor induced by BB-A. No significant change in ED 50 is observed wheh L-dopa is combined with BB-A or oxotremorine. Our work proves that BB-A possesses significant central M-cholinergic effect, and may be a hopeful tool drug in screening antiparkinsonistic agent.更多还原