【摘要】 在还原剂存在下,新抑癌素的生色团与核酸作用生成加合物。本文比较了几种还原剂对加合物的生成量的影响,发现DTT存在时加合物的产量大为增加,且加合物性质稳定。这种稳定的加合物可用于研究其结构,从而有助于阐明新抑癌素作为抗癌药的作用机理。更多还原

【Abstract】 In the presence of reductants, the interaction between the chromophore of neocarzinostatin (NCS) and the nucleic acids yielded an adduct, In this study, we compared the effects of various reductants on the amount of adduct produced. Results supported the conclusion that in the presence of DTT, the amount of adduct produced was greatly increased, and the quality of adduct was steady. This stable adduct could be used in the investigation of its structure, thus helping to understand the mechanism of NCS to act as an anticancerous drug.更多还原