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在北京地区发现的异常血红蛋白——Hb Q Thailand(α74(EF3)Asp-His)
A Hemoglobin Variant Found in Beijing——Hb Q Thailand (α74 (EF3) Asp-His)
【摘要】 1981年9月,我们用醋酸纤维素薄膜电泳法对我院义务献血员进行异常血红蛋白普查时,发现一例慢速异常血红蛋白,位于HbA与HbA2之间,相当于Q组。采集先证者血样进行化学结构分析,证明为HbQThailand。 1958年,Valla等首先在一居住在新加坡的中国人家庭中发现了HbQ复合HbH病,当时未进行结构分析。随后在我国台湾、泰国和日本相继发现,命名为HbG Thaich—ung[α74(EF3)Asp→His]或HbQ Thailand。曾氏在我国大陆首次报道,至今国内已发现多例,多在南方。在我国北方尚未见报道。
【Abstract】 In 1981, an electrophoretically slow moving hemoglobin variant was found by cellulose a cetate electrophoresis among the healthy people in Beijing. This a bnormal zone migrated between Hb A and Hb A2 and occupied a position in the Q group. Structure studies demonstrated that this homoglobin variant was Hb Q Thailand. Valla et al first reported Hb Q Thailand combined with Hb H in a chinese family of singa pore in 1958 without performing any structure analysis. This variant was subsequently reported in Thaiwan, Thailand, and Japan, and was named Hb G Thaichung (α74 (EF3) Asp→His) or Hb Q Thailand. Zheng first reported in main land of China. Up to now, many of this variant have been reported in the south, but has never been reported hitherto in the north.
- 【文献出处】 北京第二医学院学报 , 编辑部邮箱 ,1985年03期
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