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大蒜阻断细菌对亚硝胺合成的促进作用

THE BLOCKING EFFECT OF GARLIC EXTRACT ON BACTERIA-MEDIATED NITROSATION

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【作者】 刘近周; 林希蕴;

【Author】 Liu Jinzhou Lin Xiyun (Dept.of Nutrition & Food Hygiene, Shandong Medical College)

【机构】 山东医学院卫生系营养与食品卫生学教研室; 山东医学院卫生系营养与食品卫生学教研室;

【摘要】 通过实验观察到大蒜提取液可阻断大肠杆菌、肠球菌对二乙基亚硝胺、二丁基亚硝胺合成的促进作用,并有阻断大肠杆菌使硝酸盐还原为亚硝酸盐的作用。

【Abstract】 Reports an experiment which was conducted to show whether the garlic extract are able to block the bacteria-mediated nitrosation or not. E.coli and enterococci isolated from the faeces of the patients were used as the organism for inducing nitrosation. Sodium nitrite and diethylamine or dibutylamine was used as the substrata. Test was carried out in the following groups. 1. control medium, in which no bacteria inoculated; 2. bacteria-inoculated medium plus garlic extraet; 3. bacteriainoculated medium without garlic extract. Results: after incubation, the concentration of DEN or DBN in the three mediums are of the following order: Medium 3>Medium l>Medium 2. This means garlic extract not only inhibits the biosynthesis of nitrosamine but also blocks the purely chemical formation of nitrosamine. In addition, garlic extract was also found to be able to block the reduction of NO3-to NO2-by E.coli. The forgoing facts suggest that garlic be used as an anticarcinogenic food, especially for the orevention of stomach cancer.

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