【摘要】 报告9例经氨苯砜治疗10年以上的晚期麻风患者的胫后神经病理变化。发现神经内的炎症浸润消退比皮损内慢。神经中氨苯砜浓度显著的低于其在血液、肌肉及皮肤中的浓度。我们认为神经内氨苯砜的浓度降低与血管腔狭窄、闭塞及神经外膜、束膜增厚有关。神经内氨苯砜低浓度是神经中病变不易消退的原因。更多还原

【Abstract】 This article reports the pathologicchanges of posterior tibial nerve in 9cases of late leprosy treated with DDS over10 years. We found that the inflamma-tory infiltration disappeared more slowerin the nerve than in the skin lesions.The concentration of DDS was muchlower in the nerve than in blood, mu-scle and skin. Thus we suggest that narrowing and obstruction of blood vesselsand the thickening of epineurium mighthave some bearing on this condition.The persistence of the pathologic changesmight be a result of low concentrationof DDS in the nerve.更多还原