【摘要】 苦豆子总碱(又称WFK)的药理作用已经在兔子、大鼠、小白鼠等实验动物上进行了研究。实验结果表明:WFK具有增加体液免疫和细胞免疫的作用,腹腔注射WFK可以引起小鼠腹腔巨噬细胞吞噬鸡红细胞的能力,ERFC形成率增加。实验也证明,WFK明显的抑制由于炎症刺激物以及巴豆油诱发的毛细血管渗出的增加。另外,发现WFK也可以抑制蛋清诱发的大白鼠后肢水肿和由圆纸片诱发的大鼠肩部肉芽肿,WFK的抗炎作用不如氢化可的松。WFK的抗菌和解热作用无效。更多还原

【Abstract】 The pharmacological effects of total alkaloides of sophora alopecuroides(WFK) on rabbits, mice and rats were studied. The experimental results showed that WFK enhanced the effect of both humoral and cellular immunity. Intraperitoneal injection of WFK increased in the ability of maerophages phagocytosis on cock RBC in abdominal cavity. ERFC was also increased.WFK significantly inhibited capillary permeabilities induced by phlogistic stimulants and exudation induced by croton oil. Both the edema of the hind paw in rats by means of egg-white and the granuloma formation in the shoulder of rats by a round paper were inhibited. It has a moderate anti-inflammatory effect as compared with hydrocortisone. No anti-bacterial and antipyretic actions were found.更多还原