【摘要】 目前对胆系严重感染的抗生素治疗,仍存在不少问题。常用的庆大霉素对革兰氏阴性细菌有广谱抗菌作用,但以静滴或肌注给药均不能在胆汁中获得高的有效药物浓度。本研究为寻求新的给药途径,提高抗生素在胆汁中的浓度,采用经脐静脉插管、间隙推注庆大霉素,按时收集胆汁测定药物浓度,并与周围静脉给药对照,结果发现脐静脉推注庆大霉素在胆汁中的浓度是周围静脉给药的两倍以上,并且出现双峰代谢现象。这可能是经脐门脉静脉给庆大霉纱治疗严重肝胆感染获得良效的原因。更多还原

【Abstract】 The purpose of this study is to compare GM levels in bile via umbilical vein injection with those via a peripheral vein. 26 patients who underwent biliary tract operations wcre divided into two groups. 20 cases recieved GM via umbilical vein injection in a single dose of GM 1.2 mg/kg,the rest via peripheral vein injection. The mean peak levels of GM in bile were 4.04 and 2.30 ug/ml respectively. They were equal to 37％ and 22％ of the mean serum levels, prolonged studies in 8 of 20 patients showed that GM level was still present effective in bile 5 days after the operation. The inhibitory concentration (4 ug/ml) of GM in bile was used to define what was considered to be an "adequate" level in patients with biliary disease However, using other administration regime, both the bile and the serum concentrations of GM were too low to be of therapeutic value. These results showed that the new administration regime not only improved GM level in bile but also obtained a good clinical effect.更多还原