【摘要】 为了直接提高靶器官抗生素有效浓度而选择自门静脉途径给药来治疗胆系感染。本文设计了家犬经门静脉间歇推注庆大霉素与外周静脉注射对比,测定血、胆汁、肝组织匀浆中的抗生素浓度分布,结果经门静脉给药,明显提高了肝胆靶器官组织中药物浓度,表明在不增加剂量情况下局部定向给药并耒增加毒性且提高了局部药物浓度,因此作者认为,这是一条良好的治疗胆道感染的给药途径。更多还原

【Abstract】 An animal study was designed to determine whether the effective concentrations of GM. in bile and hepatic tissue could be influenced by different ways of injection. 6 normal dogs served as experimental animals and were divided into 2 groups. GM was injected via the portal vein in experimental group and by a peripheral vein in control group.In all animals, after injection, the GM levels in bile, serum and hepatic tissue were measured. The results showed that the former route of GM injection was not only safer but also more significantly increased the GM levels in bile and liver as well as the biological responses in blood than the latter route. There were no toxic responses and no hepatic damage in either group. We believe that GM delivered via the portal vein for treatment in biliary tract infections would be better than that via a peripheral vein.更多还原