【摘要】 将雄性Wistar大鼠分:年轻组(2～3月龄)、成年组(12～13月龄)和老年组(21～22月龄),每年龄组24只;实验组、对照组各12只。实验组饲料加入中药8591共喂120天。结果发现,老年对照组大鼠睾丸明显萎缩,颜色较暗,重量为0.91±0.33克,实验组睾丸表面光滑,粉红色,饱潮,重量为1.86±0.21克;镜下见对照组曲细精管数和精子数显著少于给药组。老年实验组血浆睾酮水平降低,雌二醇水平升高,T/F降低,血清LH水平升高,下丘脑MAO水平增高等变化的程度,显著小于对照组。本研究的结果表明,中药8561明显地延缓了雄性大鼠下丘脑、垂体和性腺的老化过程。更多还原

【Abstract】 Male Wistar rats of 2—3 mon.(young),12—13 mon,(adult)and 21—22 mon.were respectively divided into treated and control groups,12 rats in each group.Treated rats were fed with food containing a kind of traditional Chinese medicine,"8591",for 120 days.The results showed that weights of testes were 0.91±0.33g.,and testes looked atrophied and dark in old control rats.However weights of testes were 1.86±0.21 g.,and testes looked smooth,pink and plump in old treated rats.Under microscope,the number of testis convoluted tubules and sperm in old control rats were significantly decreased compared with those in old treated rats.Plasma levels of testosterone(T)in old treated rats were significantly higher, levels of plasma estradiol(E)and serum luteilizing hormone(LH)and MAO activity in hypothalamus lower,and T/E higher than those in old control rats.The paper suggested that"8591"significantly delayed aging of hypothalamus,pituitary and gonad in male rats.更多还原