【摘要】 <正> 近年来,儿茶酚胺与心肌坏死之间的关系引起人们的关注。据报道,在心肌梗塞的急性期,内源性儿茶酚胺的大量释放,是扩大心肌坏死面积,促使病情恶化的主要因素。因此,应用某种手段保护心肌有重要的临床意义。β受体阻断剂、抗脂类分解剂和钙拮抗剂对心肌均有不同程度的保护作用,但其副作用使临床应用受到限制。据报道,辅酶Q₁₀(Coenzyme Q₁₀,CoQ₁₀)对心肌有明显的保护作用,本实验室的工作亦表更多还原

【Abstract】 The Protective effect of coenzyme Q₁₀ on isoproterenol-induced myocardiallesion in rats was studied with histopathology and histochemistry.Twenty ratsreceived 5mg/kg isoproterenol i.p..Eight hours after injection of isoproteren-ol,20mg/kg coenzyme Q₁₀ was intravenously given to rats once 6 hours for3 times,the placebo to the others.It was shown that the necrotic size andthe area of losing succinie dehydrogenase activity in myocardium were reducedby 25.00% and 26.65% respectively by administration of coenzyme Q₁₀.Inconclusion,coenzyme Q₁₀ has a significant protective effect on myocardium.更多还原