【摘要】 本文以形态观察、分裂指数、生长曲线,集落形成为观察指标,研究了中药白屈菜对体外人食管癌细胞(Eca—109)的作用。结果表明,白屈菜对食管癌细胞具有较强杀伤作用。其0.1、0.2mg/ml作用两天的抑制率分别为55%和61%:而同浓度的4—Fu的抑制率分别为51%和68%。白屈菜在1～2mg/ml作用两天时对109细胞的有丝分裂有显著抑制作用;并使109细胞完全丧失再繁殖能力,其对食管癌细胞的杀伤作用随药物浓度的增大和作用时间的延长而增强。更多还原

【Abstract】 The long-term cultured esophageal cancer cells (ECa-109 cell Line) were treated in vitro with water extract of chelidonium majus and 5-fluorouracil respectively. After exposure of the cells to both drugs for 48 hrs. the growth inhibitory rates of 0.1mg/ml and 0.2mg/ml chelidonium majus were 55% and 61% respectively, while the growth inhibitory rates of 5-fluorouracil at the same concentration were 51% and 68%. Mitoses of the cells were inhibited at the concentrations of 1mg/ml and 2mg/ml chelidonium majus. Exposure of the cells to 2mg/ml chelidonium majus for 48 hrs led to irreversible damage as shown by colony-forming experiment. The cytotoxic effect of chelidonium majus became stronger as the concentration was increased the exposure time lengthened更多还原