【摘要】 吡喹酮能增强大白鼠离体心房和灌流心脏的心肌收缩力,与异搏定和心得安有一定程度的拮抗作用。大剂量吡喹酮灌胃后,家兔血压和心电图无改变。恒速静脉注射3％吡喹酮可使家兔和大白鼠心率逐渐减慢,血压先上升后下降;当注射量加大时出现心律失常。更多还原

【Abstract】 Experiments on the isolated atrium and perfused heart of rats showed that pyquiton (Praziquantel) had positive inotropic effect which can be antagonized by Propranolol and Verapamil. No change was demonstrated on blood pressure and ECG when large dosage (1-2g/kg) of Pyquiton was administered orally in rabbits. But the heart rate reduced gradually, blood pressure increased first and decreased later and then arrhythmia appeared when Pyquiton was administered by constant intravenous infusion in rabbits and rats.The positive inotropic effect of Pyquiton may increase myocardial oxygen demand and then induce angina pectoris. Disorder of cardiac rhythm was observed When Pyquiton was administered intravenously but it did not appear orally even in large doses. It may be related to the strong "first pass effects" of the Pyquiton after oral administration.更多还原