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舒肝健脾汤对大白鼠捆绑性胃溃疡的防治作用及对丘脑和血浆环核苷酸的影响

EFFECT OF"SHUGANJIANPI"DECOCTION ON GASTRIC STRESS ULCER AND CYCLIC NUCLEOTIDES IN RATS

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【作者】 潘其民; 李学文; 陈国林; 王勇华; 黎杏群;

【Author】 Pan Qimin Li Xuewen Chen Guolin Wang Youghua Li XingchunResearch Section of Basic Theory of Traditional Chinese Medicine,The First Affiliated Hospital,Hunan Medical College

【机构】 湖南医学院第一附属医院中医基础理论研究室; 湖南医学院第一附属医院中医基础理论研究室;

【摘要】 本文报道舒肝健脾汤对大白鼠捆绑性溃疡有明显的治疗作用。经本方治疗后,其丘脑和血浆的cGMP 水平比对照组低,血浆cAMP/cGMP比值则明显升高。

【Abstract】 The drug effect of shuganjianpi decoction (Radix Bupleuri柴胡, Radix codono-psitis党参,Cyperus rotundus L香附, Gurcuma cromatica salisb郁金,Dolichos lablab L 扁豆)on the prevention and treatment of the gastric stress ulcer, and on the level of the cyclic nucleotides in plasma and thalamus in rats is reported. The results showed that the effect of decreasing the number of gastric ulcers was obvious in treatment but not in prevention.After tr3atment,the c GMP level of their thalamus and plasma in the treated group is lower than that in the control group(P<0.05), while the cAMP/cGMP values of their plasma is higher than that of the control group(P<0.05).

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