【摘要】 本文参用Velaskar血小板聚集性检查方法研究了654-2对内毒素血症狗肺解聚微聚物功能的影响。结果表明:654-2能保护内毒素血症狗的肺解聚功能,解聚血中的微聚物和减轻内毒素血症早期的低血压和通气障碍。提示654-2治疗感染性休克、ARDS等症,可能与保护肺非呼吸功能有关。更多还原

【Abstract】 This work studied the effect of Anisodamine (primarily extracting form a Chinese herbal medicine) on one of the pulmonary non-respiratory functions: disaggregating platelet microaggregates (MA) in endotoxemic dogs.The results showed that the platelet aggregating rates (PAR) in left ventricular blood (LVB) were significantly lower than that in right atrial blood (RAB) in normal anesthetized dogs (p<0.05). After Anisodamine injection, the PAR of experimental animals (N = 11) decreased (p<0.05); whereas the controls (N= 11) remained unchanged. 60 minutes after dead E coli injection, there was no longer any difference of PAR between RAB and LVB in the controls, and remained as such later, but this difference of Anisodamine-treated dogs existed throughout the experimental period. Also, Anisodamine minimized the early increades of PAR and decreases of blood pressure and PaO2 induced by endotoxin.These data suggest that 1) Anisodamine may protect pulmonary disaggregating function of endotoxemic dogs; and 2) Anisodamine may disaggregate MA in peripheral blood and attenuate the early effect of endotoxin. We conclude that the efficacy of Anisodamine in clinical treatment probably relates to its effect on the non-respiratory functions of the lungs.更多还原