【摘要】 <正> 肾上腺髓质和心肌显像的放射性药物研究颇受人们注视。1980年Wieland等制备了放射性碘标记间碘苄胍（简称MIBG）,在肾上腺显像方面取得较为满意的结果。1982年Hanson报道了一个新的芳烷基胍的化合物——碘标记1-羧脒基-4-苯基哌嗪（简称^*I-CPP）,它对肾上腺亦有良好的选择性,且能快速标记和易于纯化。鉴于I—CPP有可能成为肾上腺髓质显像剂,故我们合成了重要中间体4-苯基哌嗪和研制了¹³¹I-CPP,以供药理和临床研究用。更多还原

【Abstract】 This report describes the synthesis of radioiodinated 1-carboxamidino-4-phenylpipera-zine--a new adrenomedullary imaging radiopharmaceutical.To 4-phenylpiperazine in water a slight excess of s-methyl-thiouronium sulfide was added. The solution was heated at reflux for 6h and then cooled to room temperature, The precipitate formed was collected and recrystallized from hot water. This compound was radioiodinated by the chloramine-T method. The iodinated tracer was purified by paper cbromatography. The yield was about 86% (from 83% to 89%). The radiochemical purity was over 98%.更多还原