【摘要】 姊妹染色单体互换分析是研究环境诱变致癌物所致遗传损伤的灵敏方法。本研究分析了12名焦炉作业工人外周血淋巴细胞SCE值。作业工人的暴露年限为15至32年,平均21.3年。其SCE均值为每中期细胞13.04±1.47(SD)。健康对照组SCE均值为每中期细胞8.82±1.26(SD)。两组间有非常显著的差异(P<0.001)。结果提示,SCE值的增高与接触焦炉逸散物有关。应当引起重视。更多还原

【Abstract】 The analysis of sister chromatid exchange (SCE) might be a useful technique for the study of genetic damage in humans exposed to enviromental mutagens and carcinogens. In the present study lymphocyte sister chromatid exchange frequencies were determined for 12 long-term coke oven workers and 20 controls. The duration of exposure to the coke oven emissions ranged from 15 to 32 years. The mean SCE frequency for the exposed group was 13.04±1.47 (SD) SCEs per cell and that for the control group was 8.82±1.26 (SD) SCEs per cell. A highly significant difference (P<0.001) was observed. The present results indicate that the increased SCE frequency in coke oven workers may be related to the long-term exposure to coke oven emissions.更多还原