【摘要】 本文研究了二种或三种多环芳烃（PAH）并存时对AHH活性的影响。10种PAH被分为6组;1)蒽和菲（3环）;2)苯并（a）蒽和（艹屈）（4环）;3)苯并[e]芘（BeP）和苝（5环）;4)苯并[ghi]芘和蔻（6环和7环）;5)7,12-二甲基苯并[a]蒽（DMBA）和3-甲基胆蒽（MCA）（强致癌性）;6)DMBA、MCA和BeP（三种PAH并存）,实验按正交表L₄（2³）和L₈（2⁷）设计,AHH活性用液闪法测反应终止后反应液水相中的放射性。结果表明,各组都有轻度至中度抑制AHH活性的作用,特别是第5和第6组更为明显,PAH对AHH活性的联合抑制作用可以部分解释PAH对BaP致癌的竞争抑制效应。更多还原

【Abstract】 In this paper, a combined action of 2 or 3 PAH on AHH activity was studied. 10 PAH were divided into 6 groups:1) anthracene and phenanthrene (3-cyclic),2) benz (a) anthracene and ctrysene (4-cyclic), 3) benzo (e) pyrene (Bep) and perylene (5-cyclic) , 4) benzo (ghi) perylene and coronene (6-and 7-cyclic),5)7,12-dimethylbenz(a)anthracene(DMBA)and 3-methylcholanthrene (MCA)(strong carcinogenic), and 6)DMBA, MCA, and BeP (3 PAH coexisted). The experiment was designed according to the orthogonal L4(23)and L8(27) tables. The quantitation of AHH activity was based on the scintillation counting of the radioactivitv of the lower phase of the reaction medium after stop of reaction.Theresults showed a slightly to moderately inhibiting action on AHH activity in all groups,notably in the 5th and 6th group.It is suggested that the combined inhibiting action of PAH on AHH activity may partially explain the competitive inhibitory effect of PAH on BaP carcinogenesis.更多还原