【摘要】 本文选用大鼠研究了甲醇对CCl₄肝毒性的加强作用,其程度随剂量的不同而有很大差异,最大加强作用的时间为36—48小时。甲醇预处理能引起体内、体外脂质过氧化作用,但对CCl₄引起的脂质过氧化无明显加强作用。另一方面,甲醇预处理对鼠肝MFO活性,特别是对Cytp₄₅₀及Cytb₅无明显影响,但能明显降低大鼠肝脏巯基含量,因此,可能是甲醇加强作用的机理之一。更多还原

【Abstract】 Methanol potentiation of CC14-induced hepatotoxicity was observed in rats, The degree of potentiation had been shown to vary considerably from low to high doses of methanol. The time course for the highest potentiation ranged from 36 to 48 hours.Methanol pretreatment induced lipid peroxidation both in vivo and in vitro but did not significantly potentiate the amount of CCl4-induced lipid peroxidation. On the other hand, methanol pretreatment had no effect on hepatic MFO activity,especially cytochrome P-450 and cytochrome b5, but it could significantly reduce the SH-radical amount of liver in rats.Therefore it might be one of the possible me chanisms of methanol potentiation.更多还原