【摘要】 本文采用HPLC法,研究了8名正常人与7名心律失常患者在口服单剂量300mg心律平后的药代动力学。4名空腹服药者与饱腹服药者的药代动力学参数比较结果,除“Tm”有极显著差异外(p<0.01),其它均无显著差异。肝肾功能正常病人的药代动力学参数与正常人相似,而2例肝或肾功能损害者,心律平在体内消除较为缓慢。正常人与肝肾功能正常病人的t(1/2)分别为2.29±0.49(n=8)和2.28±0.31h(n=5),而肝或肾功能损害者的t(1/2)为4.33±0.33h(n=2)。更多还原

【Abstract】 The pharmacokinetics of propafenone were studied in 8 normal subjects and 7 patients with cardiac dysrhythmias after a single oral dose of 300mg by HPLC method. Pharmacokinetic parameters were compared between theadministrations before and after breakfast in 4 subjects. "Tm" was found tobe a significant difference (p<0.01), and there was no significant differen-ce to the other parameters. The mean half-life were 2.28±0.3h (n=5) in thepatients with noral renal and liver functions and 2.29±0.49 h (n=8) in thehealthy subjects, however, two patients with impaired renal or liver functionshowed a significantly longer half-life of propafenone (4.33±0.33h).更多还原