【摘要】 <正> Russell于1971年首先报告,转移癌患者尿多胺排泄量增加,实体肿瘤和血液肿瘤患者尿多胺水平亦展示一定型式的增高,而且其增高程度与肿瘤活性相关,故认为尿多胺水平可作为估价肿瘤活性的一种诊断工具。嗣后许多研究者将多胺作为肿瘤的生化标志,探讨各种体液多胺测定的临床应用价值。Durie曾报告血液肿瘤和实体肿瘤患者尿液中腐胺,精脒和精胺的浓度均显著增高,其中精胺值范围在癌患者与正常志愿者之间并无重叠更多还原

【Abstract】 We detected spermine by the method of improved spermine reaction in serum and gastric juice samples from patients with various stomach diseases and control population. Among the 342 eases whose serum samples were exa- mined, the positive percent of the reaction was respectively 68. 2% (30/414) in stomach cancer group, 30. 5%(54/177) in benign gastric lesion group, and 13. 2% (16/121) in control population group. The positive percent of stomach cancer group was higher than those of benign gastric lesion group and control population group (p<0. 01). Among 162 cases whose gastric juice samples were examined, the positive percent of the reaction was respectively 75. 8%(25/33) in stomach ca- ncer group, 48. 1%(62/129) in benign gastric lesion group. The positive perce- nt of stomach cancer group was higher than that of benign gastric lesiongro- up(0. 05>p>0. 01).The results suggest that the detection of spermine in serum samples may be of certain value in screen, diagnosis and monitor of stomach cancer patients.更多还原