【摘要】 <正> Pelger-Huet白细胞异常自1928年首先由Pelger报告以后,国内外均有报道。现将我院1例遗传性Pelger-Huet氏白细胞异常及其家族34人调查情况报告于下。病例摘要患者男性、16岁,辽宁省盖县人,中学生。因间断发烧、肝脾淋巴结肿大、关节骨骼疼痛、反复皮疹1年,经3次住院,诊断为“免疫母细胞淋巴腺病”。患更多还原

【Abstract】 Pelger-Huet anomaly of leucocytes is characterized by failure of normal lobe development in cells of granulocytic series. These neutrophils have one or two lobes per nucleus, cells that have more than three lobes per nucleus are seldom. Most of the mature neutrophils are characterized by smaller nuclei with clumped chromatin. The development of cytoplasm is normal and does not appear to affect neutrophil function. The cells below the stage of metamylocyte in bone marrow have the same anomaly to peripheral blood.This report shows the data which were collected from a male who had suffered from Pelger-Huet anomaly and his family whom we had investigated. The peripheral blood smear taken from 34 members of the family was examined. There are 14 members have Pelger-Huet anomaly of neutrophils, its genetic nature being quitet distinct. It is important to distinguish the hereditary anomaly and false Pelger-Huet anomaly. The latter may be acquired from severe infection, leukemia, myeloma etc.更多还原