【摘要】 用¹²⁵Ⅰ-心钠素放射自显影和受体分析法证明,在大鼠肾脏、血管壁和人的血管床上有心钠素的特异结合部位。这种结合可以特异地被人工合成的心钠素所竞争、取代,而不能被其他的肽所竞争、取代。放射自显影显示,这些特异结合部位主要分布在肾小球、肾脏皮、髓质交界处肾小管的上皮细胞和血管壁的平滑肌细胞。更多还原

【Abstract】 Using ¹²⁵Ⅰ-atriopeptin as a radioligand, we observed the binding of atriopeptin with receptor membrane prepared from the rat and human kidney. The binding in human and rat kidneys could be competatively replaced by the synthetic atriopeptin, but not by leu-enkephalin, dynorphin, or CCK.The distribution of atriopeptin receptors was determined by autoradiography in the kidney and blood vessels of rats. Areas showing dense distribution of atriopeptin receptors included the epithelium of tubuli renales, especially in tubuli renales between cortex and medulla renis, and the smooth muscles of the aorta.更多还原