【摘要】 半胱胺可以引起大鼠体内生长抑素耗竭并诱发十二指肠溃疡。本工作发现,腹腔注射牛胰多肽可以减轻半胱胺引起的大鼠十二指肠溃疡,还可防止半胱胺引起的大鼠十二指肠粘膜生长抑素含量的下降。这项工作提示,牛胰多肽可能通过防止局部生长抑素的耗竭对十二指肠起到保护作用。更多还原

【Abstract】 Cysteamine can deplete tissue somatostatin (SRIF) and induce duodenal ulcers in rats. It was observed that bovine pancreatic polypeptide (BPP) inhibited cysteamine-induced duodenal ulcers, and prevented cysteamine-induced SRIF depletion in duodenal mucosa in rats. It suggests that BPP may protect duodenal mucosa from ulceration by preventing local SRIF depletion caused by cysteamine.更多还原