【摘要】 本文观察了黄腐酸对消炎痛或酒精引起的大鼠胃损伤和胃粘膜前列腺素E生成的影响。结果表明:(1)消炎痛能明显地抑制正常大鼠胃粘膜PGE的生成,同时胃粘膜发生严重损伤。(2)消炎痛对胃粘膜PGE生成的抑制作用能被黄腐酸所翻转,同时胃粘膜损伤的形成明显减少。(3)黄腐酸对正常大鼠胃粘膜PGE的生成无影响。(4)黄腐酸对无水酒精引起的胃损伤具有明显的细胞保护作用,但对胃粘膜PGE的生成并无影响。更多还原

【Abstract】 Non-antisecretory dose (10mg/kg) of fulvic acid was injected subcutaneously into the rats 1 minute before the subcutaneous administration of indomethacin (20mg/kg). The animals were killed 4 hours after indomethacin. In another group of rats the pylorus was ligated and non-antisecretory dose (5mg/kg) of fulvic acid was given orally 1 minute before oral administration of absolute ethanol (1ml). The animals were killed 1 hour after receiving ethanol. The results showed that: (1) Indomethacin inhibited the production of gastric mucosal PGE in the normal rats and the gastric mucosa developed severe lesions. (2) The effect that indomethacin inhibited the production of mucosal PGE was reversed by fulvic acid and the mucosal lesions formed by the indomethacin was reduced. (3) Fulvic acid had no effect on the production of mucosal PGE in normal rats.We also observed in this study that fulvic acid prevented significantly the ethanol-induced gastric lesions, but it had no effect on the production of mucosal PGE.更多还原