【摘要】 在大鼠异丙肾上腺素心肌损伤模型上,654-2或戊脉安显著保护其心肌损伤和抑制其心肌钙含量的增加。在高钾去极化的豚鼠迴肠条上,654-2显著抑制其对Ca²⁺的收缩反应,实验结果表明,654-2具有明显的钙拮抗作用。654-2的这种作用,可能是其细胞保护作用的重要机制之一。更多还原

【Abstract】 When tissues are damaged by various pathogenetie factors such as ischemia or hypoxia, accumulation of Ca⁺⁺ within the cells is the main cause of cellular irreversible damage. In this study, myocardial damage in rats was induced by subcutaneous injection of isoprenaline, and the Ca⁺⁺ content of the myocardium in isoprenalinetreated rats was found to be 3-fold as high as that in the control animals （11.95±0.72 vs 3.18±0.31 mEq/kg dry wt, p<0.001）. In the animals pretreated with 654-2 or verapamil, the damaging effect of isoprenaline was significantly ameliorated, and the isoprenaline-induced increase in myocardial calcium content was significantly reduced （5.35+1.08 and 3.65+0.49 mEq/kg dry wt respectively）. Tests in vitro showed that 65,1-2（0.1 mg/ml） inhibited the contraction of hyperkalium-depolarized guinea pig’s intestinal strip in response to the addition of Ca⁺⁺. The results indicated that 654-2 possesses a calcium-antagonist effect and, probably, the calcium-antagonist effect of 654-2 is one of the important mechanisms through which 654-2 exerts protective action against cellular damage.更多还原