【摘要】 <正> 柠檬酸铝配合物对防治动物实验性矽肺有很好的效果,临床试用也确认有一定的疗效。我们设想,为避免长期用药引起体内磷代谢的紊乱,应适当补磷;为有利于矽肺併发症肺炎、肺结核的治疗,可同时给抗炎、抗结核药物。因此,选择了α-甘油磷酸(α-GP)、四环素(TC)及对氨基水杨酸(PAS)分别与铝更多还原

【Abstract】 Three systems, Al(Ⅲ)-Cit-α-GP, Al(Ⅲ)-Cit-TC and Al(Ⅲ)-Cit-PAS were studied by means of pH potentiometric titration.With the previously proposed method, the log formation constants of the mixed ligand complexes, Al(Ⅲ)-Ci-α-GP Al(Ⅲ)-Cit-TC and Al(Ⅲ)-Cit-PAS were determined. The constants were 14.84 (S. D. 0.16), 18.11 (S. D. 0.25) and 22.20 (S. D. 0.22) respectively at 25.0± 0.1℃ in the presence of I=0.10 and in a nitrogen atmosphere. The distribution diagrams of complex species in the three systems are also presented in the article.The mixed ligand complexes are could be used as pharmaceuticals for treatment of silicosis with supplementary action to compensate phosphorus deficiency due to aluminum uptake (Al(Ⅲ)-Cit-α-GP), and to inhibit inflammation (Al(Ⅲ)-Cit-TC) or tuberculosis (Al(Ⅲ)-Cit-PAS).更多还原