【摘要】 <正> 休克过程由于内脏缺血,常常伴有肠道内分泌的紊乱。休克时循环中胰多肽(Pancreatic Polypeptide, PP)、血管活性肠肽(Vasoactive intestnal peptde, VIP)等多种肠道激素的活性显著增加,但其病生理意义尚不清楚。崎尾等认为VIP由于有扩张血管效应和正性心力作用对身体有保护意义;反之,Bateon等则认为其严重低血压效应反而促进休克的恶化。更多还原

【Abstract】 The role of gut hormones in the pathogenesis of shock was studied on rabbit’s superior mesenteric artery occlusion(SMAO) shock model, observing the effect of perfusion of 0.2 μg/kg of pancreatic polypeptide (PP) and of 0.2 μg/kg of vasoactive intestinal peptide (VIP) via femoral vein or SMA on shock process. The result showed that intravenous perfusion of these two hormones exerted no significant influence on the shock process; while PP perfusion via SMA significantly relieved animals from isehemic intestinal tissue damage and improved its prognosis. In contrast with PP perfusion, VIP perfused via SMA significantly deteriorated shocked intestine. The results suggest that PP, as a local gut hormone, may have protective effect on shock animals, but VIP, in the contrary, may take part in the pathogenesis of SMAO shock.更多还原