【摘要】 血卟啉衍生物(HpD)在动物体内及恶性肿瘤组织内分布的研究,可以给HpD—光动力治疗提供重要依据。采用~8H-HpD,注入载瘤小鼠剂量为300μci,并采用整体放射自显影术,对分布问题进行了研究。结果表明,~3H—HpD注入实验动物后1～96小时,骨骼肌内含量一直低于肿瘤,到48小时以后,皮肤含量也低于肿瘤。肝脾肾的含量始终较高。未见恶性肿瘤组织对血卟啉衍生物有特异的摄取和潴留。更多还原

【Abstract】 The distribution of 3H-HpD in organs and cancel of tumor-bcaring mice was studied by whole body autoradiography.The accumulation of tracer was found in high level in liver, spleen, and kidney in 1 to 96 hrs after inicction. The tumor for tracer had no prominent accumulation and uptake.更多还原