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猪去氧胆酸的离解常数和活度积常数的测定

Determination of the Dissociation Constant and Activity Product of the Hyodeoxycholic Acid

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【作者】 华惠珍周凯刘坚

【Author】 Hua Huizhen Zhou Kai Lu Jian Department of Chemistry

【机构】 北京大学化学系北京大学化学系北京大学化学系 79级学生78级分校学生

【摘要】 <正> 猪去氧胆酸(Hyodeoxycholic acid)的结构式见图1,目前是一种降血压药的主要成分,又有可能用于试治胆结石症。它的离解常数(Ka)、活度积常数(Ksp0)及临界胶束浓度(CMC)尚未见报道,这些参数对于了解它在胃肠中的吸收等

【Abstract】 Hyodeoxycholic acid is slightly soluble in water. For determining its Ka and KS0P, it is dissolved in NaOH and then titrated with 4 × 10-3M HCl. Internally electrogene-rated hydroxyl ion instead of reagent NaOH is used, which improve the precision of determination and the rate of titration. The pKa and pKs0p obtained are 5.17-6.12 and 9.07-9.25 respectively, the former increases and the later decreases with the increase of the concentration of sodium hyodeoxycholate titrated.The critical micellar concentration of hyodeoxycholate is determined by surface tension method.

  • 【文献出处】 北京大学学报(自然科学版) ,Acta Scicentiarum Naturalum Universitis Pekinesis , 编辑部邮箱 ,1985年01期
  • 【被引频次】3
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